I came across this very interesting theoretical paper about enhancer evolution a couple of months ago1 and thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well …
I really enjoyed Eric Mendenhall's 2013 paper in Nature Biotechnology1, where he was able to target LSD1 histone demethylase activity to endogenous enhancers using TALE fusion proteins (read my thoughts on that paper here). So I was very interested to see a similar approach published earlier this year in …
Back to eRNAs, and this time we're going to look at possible roles in DNA damage control. This paper by Melo et al. is from Reuven Agami's lab at the Netherlands Cancer Institute. The abstract is as follows:
Binding within or nearby target genes involved in cell proliferation and survival …
Moving away from enhancer/promoter looping for a little while, I came across this nice paper from the Bernstein lab at the Howard Hughes Medical Institute. This paper is about assigning enhancers to their cognate genes, and also has some interesting implications for the causality of histone modifications on active …