Post tagged: Journal Club

Enhancer Journal Club: eRNAs are required for p53-dependent enhancer activity and gene transcription.

Back to eRNAs, and this time we're going to look at possible roles in DNA damage control. This paper by Melo et al. is from Reuven Agami's lab at the Netherlands Cancer Institute. The abstract is as follows:

Binding within or nearby target genes involved in cell proliferation and survival …

Enhancer Journal Club: Locus-specific editing of histone modifications at endogenous enhancers.

Moving away from enhancer/promoter looping for a little while, I came across this nice paper from the Bernstein lab at the Howard Hughes Medical Institute. This paper is about assigning enhancers to their cognate genes, and also has some interesting implications for the causality of histone modifications on active …